Ratio of Th17/Treg and Disease Activity in Systemic Lupus Erythematosus
نویسندگان
چکیده مقاله:
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by T-cells imbalance. There are ongoing controversies about the role of specific T-helper cell subsets and their cytokines. The study aimed to confirm the disturbance of Th17/Treg ratio in SLE patients. Methods: Subjects were SLE patients who met the American College of Rheumatology 1997 criteria. Disease activity assessment was measured by SLAM index. Th17 and Treg level was measured by flow cytometry. Th17 level was evaluated as CD4+L17 whilst Treg as CD4+Foxp3+. Final result is stated as Th17/Treg ratio. Results: Thirty female subjects with active SLE had mean SLAM Score of 29.3±3.88, C3 level 25.2 (6-59.5), C4 level 15.25 (5-54.3), ESR 62.1±37.85, CRP 30.16±59.45, and anti-dsDNA 155.32±186.10. Higher Th17 level was found in SLE patients compared to healthy subjects (30.09 pg/ml vs 13.01pg/ml; 12.60% vs 0.91%). However, it did not correlate to disease activity (p>0.05; r=-0.28). Regarding Treg level, there was no significant difference between active SLE and healthy subjects (12.85 vs 11.05 pg/ml; 9.57% vs 2.05%). Treg level negatively correlated to SLE disease activity (p<0.01; r=-0.73). Th17/Treg ratio was 3.28±2.22% and it positively correlated to SLE disease activity (p<0.01; r=0.78). Conclusion: Th17/Treg ratio is positively correlated with disease activity. Th17 level is elevated but not correlated with disease activity. Decrease of Treg level is not significant though correlated with disease activity in SLE patients.
منابع مشابه
Neurobrucellosis in systemic lupus erythematosus
Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...
متن کاملRare Association between Kikuchi's Disease and Systemic Lupus Erythematosus
Histiocytic necrotizing lymphadenitis or Kikuchi's disease is a rare, benign condition of unknown etiology, which is usually characterized by cervical lymphadenopathy and fever. This disease is rarely associated with systemic lupus erythematosus. Here we describe, for the first time in Iran, a patient who developed systemic lupus erythematosus about 3 years after the initial diagnosis of Kikuch...
متن کاملCutaneous Manifestations of Systemic Lupus Erythematosus in Iranian Children
Systemic lupus erythematous (SLE) is an autoimmune process in which cutaneous lesions occur in majority of patients. This study was conducted to determine the pattern and prevalence of such lesions in SLE in Iranian children infected with SLE. Forty-eight patients, age between 3-16 yrs and male to female ratio of 7/1 were examined for the presence of cutaneous manifestations of SLE. The most co...
متن کاملA Case of Systemic Lupus Erythematosus
SUMMARY During the course of systemic lupus erythematosus in a 10 year-old girl, a go it er develo ped. Subc linical I ly pothyrnic.Jism was found, in addition rising titer of ant imicrosomal antibody and overt hypothyroidism after 6-week cessation of thyroxin tablet lead to the diagnosis of Hashimoto's thyroiditis. Antibodies directed to the thyroid may result in an autoimmune thyroiditis in...
متن کاملHematologic manifestation of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. The most common hematologic finding is anemia, leukopenia, thrombocytopenia and secondary antiphospholipid syndrome with recurrent abortion and thrombosis. The autoimmune fibrosis of bone marrow is another manifestation of autoimmune disease especially SLE, that must be correctly differentiated from primary myelofibrosis.
متن کاملAnticardiolipin Antibodies in Juvenile Rheumatoid Arthritis and Systemic Lupus Erythematosus
Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 10 شماره 1
صفحات 65- 72
تاریخ انتشار 2019-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023